Recombinant Human Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1)

Uniprot Id

Q9UHR4

Target Species

Human

Target Name

BAIAP2L1

Target Full Name

BAR/IMD domain-containing adapter protein 2-like 1

Target Function

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.

Target Subcellular Location

Cytoplasm, cytoskeleton. Note=Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.

Target Synonyms

BAI1 associated protein 2 like 1; BAI1 associated protein 2 like protein 1; BAI1-associated protein 2-like protein 1; Baiap2l1; BI2L1_HUMAN; Brain specific angiogenesis inhibitor 1 associated protein 2 like protein 1; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; FLJ42275; Insulin receptor tyrosine kinase substrate; IRTKS

Target Background

This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.