Recombinant Human BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1)

Uniprot Id

Q13829

Target Species

Human

Target Name

TNFAIP1

Target Full Name

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

Target Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.

Target Subcellular Location

Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes.

Target Protein Families

BACURD family

Target Synonyms

TNFAIP1; BACURD2; EDP1BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; hBACURD2; BTB/POZ domain-containing protein TNFAIP1; Protein B12; Tumor necrosis factor; alpha-induced protein 1; endothelial

Target Background

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner.