Recombinant Human BTB/POZ domain-containing protein 1 (BTBD1)

Uniprot Id

Q9H0C5

Target Species

Human

Target Name

BTBD1

Target Full Name

BTB/POZ domain-containing protein 1

Target Function

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism. May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis.

Target Subcellular Location

Cytoplasm.

Target Tissue Specificity

Ubiquitous; highest levels in testes, heart and skeletal muscle.

Target Synonyms

BTBD1; C15orf1; NS5ATP8BTB/POZ domain-containing protein 1; Hepatitis C virus NS5A-transactivated protein 8; HCV NS5A-transactivated protein 8

Target Background

The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms.