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| Cat.No | ACP17441 | Target Name | KCTD21 |
|---|---|---|---|
| Target Synonyms | KCTD21BTB/POZ domain-containing protein KCTD21; KCASH2 protein; Potassium channel tetramerization domain-containing protein 21 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-260 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q4G0X4 |
|---|
Uniprot Id
Q4G0X4
Target Species
Human
Target Name
KCTD21
Target Full Name
BTB/POZ domain-containing protein KCTD21
Target Function
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB).
Target Tissue Specificity
Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma.
Target Synonyms
KCTD21BTB/POZ domain-containing protein KCTD21; KCASH2 protein; Potassium channel tetramerization domain-containing protein 21
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