Recombinant Human C-Myc-binding protein (MYCBP)

Uniprot Id

Q99417

Target Species

Human

Target Name

MYCBP

Target Full Name

c-Myc-binding protein

Target Function

May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.

Target Subcellular Location

Cytoplasm. Nucleus. Mitochondrion. Note=Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.

Target Protein Families

AMY1 family

Target Tissue Specificity

Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

AMY 1; AMY-1; AMY1; Associate of Myc 1; C myc binding protein ; C-Myc-binding protein; Cmyc binding protein; MYCBP; MYCBP_HUMAN

Target Background

The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene.