Recombinant Human C-type lectin domain family 11 member A (CLEC11A)

Uniprot Id

Q9Y240

Target Species

Human

Target Name

CLEC11A

Target Full Name

C-type lectin domain family 11 member A

Target Function

Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. Important for repair and maintenance of adult bone.

Target Subcellular Location

Cytoplasm. Secreted.

Target Tissue Specificity

Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver.

Target Synonyms

C type (calcium dependent; carbohydrate recognition domain) lectin; superfamily member 3; C type lectin domain family 11 member A; C type lectin superfamily member 3; C-type lectin domain family 11 member A; C-type lectin superfamily member 3; CLC11_HUMAN; CLEC11A; CLECSF3; LSLCL; Lymphocyte secreted C type lectin; Lymphocyte secreted C-type lectin; lymphocyte secreted long form of C type lectin; p47; Stem cell growth factor; stem cell growth factor lymphocyte secreted C type lectin

Target Background

This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined.