Recombinant Human C-type lectin domain family 7 member A (CLEC7A), Truncated

Uniprot Id

Q9BXN2

Target Species

Human

Target Name

CLEC7A

Target Full Name

C-type lectin domain family 7 member A

Target Function

Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans.

Target Involvement

Candidiasis, familial, 4 (CANDF4)

Target Subcellular Location

Cell membrane; Single-pass type II membrane protein.; [Isoform 5]: Cytoplasm.; [Isoform 6]: Cytoplasm.; [Isoform 7]: Cytoplasm.

Target Tissue Specificity

Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.

Target Synonyms

Beta GR; Beta-glucan receptor; BGR; C type calcium dependent carbohydrate recognition domain lectin superfamily member 12; C type lectin domain family 7 member a; C-type lectin domain family 7 member A; C-type lectin superfamily member 12; CANDF4; CLC7A_HUMAN; CLEC7A; CLEC7A protein; Clecsf12; DC-associated C-type lectin 1; Dectin 1; DECTIN 1 receptor; Dectin-1; Dectin1; Dendritic cell associated C type lectin 1; Dendritic cell-associated C-type lectin 1; Lectin like receptor 1; Putative transmembrane protein dectin 1

Target Background

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1, 3-linked and beta-1, 6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.