Recombinant Human C-X-C chemokine receptor type 4 (CXCR4), Truncated

To produce recombinant Human CXCR4 protein, a well-established recombinant DNA technology is the key. A DNA template of CXCR4 was constructed with N-terminal 10xHis-SUMO tag & C-terminal Myc tag using the technique. Once the template was made, the recombinant Human CXCR4 protein could be produced with it efficiently. CUSABIO has built a strict QC system to ensure quality. The expression region is 303-352aa of the Human CXCR4. The purity of this recombinant is 90% determined by SDS-PAGE. CXCR4 is a protein coding gene that encodes C-X-C chemokine receptor type 4?(CD_antigen: CD184). According to some studies, CXCR4 may have the following features.The role of CXCR4?in various diseases, including cancer and WHIM syndrome. CXCR4 expression in cancer metastases appears to be due to receptor dysregulation leading to enhanced signaling. CXCR4 regulates the growth of primary and metastatic breast cancer. CXCR4 is a prognostic marker for acute myeloid leukemia. CXCR4 plays major roles in embryonic development, homeostasis and inflammation. CXCR4 plays a key role in the crosstalk between tumor cells and their respective microenvironments, suggesting that CXCR4-targeted therapeutic approaches may become clinically important in the near future. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.

ACP02267

Number

Cat.No	ACP02267	Target Name	CXCR4
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	303-352aa	Mol Weight	25.2kDa
Protein Length	Partial of Isoform 2	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02267

Target Name

CXCR4

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

303-352aa

Mol Weight

25.2kDa

Protein Length

Partial of Isoform 2

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P61073

Background Information

Uniprot Id

P61073
Target Species

Human
Target Name

CXCR4
Target Full Name

C-X-C chemokine receptor type 4
Target Function

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.; (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.
Target Involvement

WHIM syndrome (WHIMS)
Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC).
Target Protein Families

G-protein coupled receptor 1 family
Target Tissue Specificity

Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microv
Target Research Area

Immunology
Target Synonyms

CXCR4; C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; Lipopolysaccharide-associated protein 3; LAP-3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD antigen CD184
Target Background

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Recombinant Human C-X-C chemokine receptor type 4 (CXCR4), Truncated

Specifications

Immunogen Information

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