Recombinant Human Calcium-activated chloride channel regulator 4 (CLCA4), Truncated

Uniprot Id

Q14CN2

Target Species

Human

Target Name

CLCA4

Target Full Name

Calcium-activated chloride channel regulator 4

Target Function

May be involved in mediating calcium-activated chloride conductance.

Target Subcellular Location

Cell membrane; Single-pass membrane protein. Apical cell membrane. Secreted.

Target Protein Families

CLCR family

Target Tissue Specificity

Primarily expressed in the digestive tract, mainly in colon. Detected in smaller amounts in brain, urogenital organs, testis, and salivary and mammary glands. Highly expressed in the epithelial layer and submucosal gland of the inferior turbinate mucosa.

Target Synonyms

30 kDa form; CaCC-2; Calcium-activated chloride channel family member 4; Calcium-activated chloride channel protein 2; Calcium-activated chloride channel regulator 4; Clca4; CLCA4_HUMAN; hCaCC-2; hCLCA4

Target Background

The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding.