Recombinant Human Calpain-3 (CAPN3), Truncated

Uniprot Id

P20807

Target Species

Human

Target Name

CAPN3

Target Full Name

Calpain-3

Target Function

Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53.

Target Involvement

Limb-girdle muscular dystrophy 2A (LGMD2A)

Target Subcellular Location

Cytoplasm. Nucleus, nucleolus.

Target Protein Families

Peptidase C2 family

Target Tissue Specificity

Isoform I is skeletal muscle specific.

Target Research Area

Cell Biology

Target Synonyms

Calcium-activated neutral proteinase 3; calpain 3, (p94); Calpain L3; Calpain large polypeptide L3 ; Calpain p94; calpain p94, large [catalytic] subunit; calpain, large polypeptide L3; Calpain-3; CAN3_HUMAN; CANP 3; CANP3; CANPL3; CAPN3; LGMD 2A; LGMD2; LGMD2A; Lp82; Lp85; MGC10767; MGC11121; MGC14344; MGC4403; Muscle-specific calcium-activated neutral protease 3; muscle-specific calcium-activated neutral protease 3 large subunit; nCL-1; New calpain 1; p94

Target Background

Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.