Recombinant Human Casein kinase I isoform gamma-1 (CSNK1G1)

Uniprot Id

Q9HCP0

Target Species

Human

Target Name

CSNK1G1

Target Full Name

Casein kinase I isoform gamma-1

Target Function

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate. Phosphorylates CLSPN.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily

Target Synonyms

9130020E21Rik; Casein kinase 1 gamma 1; Casein kinase I isoform gamma 1; Casein kinase I isoform gamma-1; CKI gamma 1 ; CKI-gamma 1; CSNK1G1; EC 2.7.11.1; KC1G1_HUMAN

Target Background

This gene encodes a member of the casein kinase I gene family. This family is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. The encoded kinase plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin. A mutation in this gene may be associated with non-syndromic early-onset epilepsy (NSEOE).