Recombinant Human Catalase (CAT)

Uniprot Id

P04040

Target Species

Human

Target Name

CAT

Target Full Name

Catalase

Target Function

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.

Target Involvement

Acatalasemia (ACATLAS)

Target Subcellular Location

Peroxisome.

Target Protein Families

Catalase family

Target Synonyms

Cas1; CAT; CATA_HUMAN; Catalase; Cs1; MGC138422; MGC138424

Target Background

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene.