Recombinant Human Cathepsin D (CTSD)

Uniprot Id

P07339

Target Species

Human

Target Name

CTSD

Target Full Name

Cathepsin D

Target Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

Target Involvement

Ceroid lipofuscinosis, neuronal, 10 (CLN10)

Target Subcellular Location

Lysosome. Melanosome. Secreted, extracellular space.

Target Protein Families

Peptidase A1 family

Target Tissue Specificity

Expressed in the aorta extracellular space (at protein level). Expressed in liver (at protein level).

Target Research Area

Neuroscience

Target Synonyms

CatD; CATD_HUMAN; Cathepsin D; Cathepsin D heavy chain; CD; Ceroid lipofuscinosis neuronal 10; CLN10; CPSD; ctsd; Epididymis secretory sperm binding protein Li 130P; HEL S 130P; Lysosomal aspartyl peptidase; Lysosomal aspartyl protease; MGC2311

Target Background

This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.