Recombinant Human Cell division cycle protein 23 homolog (CDC23)

Uniprot Id

Q9UJX2

Target Species

Human

Target Name

CDC23

Target Full Name

Cell division cycle protein 23 homolog

Target Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Target Protein Families

APC8/CDC23 family

Target Research Area

Cell Cycle

Target Synonyms

ANAPC8; Anaphase promoting complex subunit 8; Anaphase-promoting complex subunit 8; Apc 8; APC8; Cdc 23; CDC23; CDC23_HUMAN; cell division cycle 23; Cell division cycle 23 homolog; Cell division cycle protein 23; Cell division cycle protein 23 homolog; Cut23; Cyclosome subunit 8

Target Background

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.