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| Cat.No | ACP13179 | Target Name | CEP19 |
|---|---|---|---|
| Target Synonyms | CEP19; C3orf34; HSD5; Centrosomal protein of 19 kDa; Cep19 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-163 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96LK0 |
|---|
Uniprot Id
Q96LK0
Target Species
Human
Target Name
CEP19
Target Full Name
Centrosomal protein of 19 kDa
Target Function
Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes.
Target Involvement
Morbid obesity and spermatogenic failure (MOSPGF)
Target Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, cilium basal body.
Target Protein Families
CEP19 family
Target Synonyms
CEP19; C3orf34; HSD5; Centrosomal protein of 19 kDa; Cep19
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