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| Cat.No | ACP03792 | Target Name | COL12A1 |
|---|---|---|---|
| Target Synonyms | COL12A1; COL12A1LCollagen alpha-1(XII) chain | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 140-316aa |
| Mol Weight | 23.5kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q99715 |
|---|
Uniprot Id
Q99715
Target Species
Human
Target Name
COL12A1
Target Full Name
Collagen alpha-1(XII) chain
Target Function
Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.
Target Involvement
Ullrich congenital muscular dystrophy 2 (UCMD2); Bethlem myopathy 2 (BTHLM2)
Target Subcellular Location
Secreted, extracellular space, extracellular matrix.
Target Protein Families
Fibril-associated collagens with interrupted helices (FACIT) family
Target Tissue Specificity
Found in collagen I-containing tissues: both isoform 1 and isoform 2 appear in amnion, chorion, skeletal muscle, small intestine, and in cell culture of dermal fibroblasts, keratinocytes and endothelial cells. Only isoform 2 is found in lung, placenta, ki
Target Research Area
Signal Transduction
Target Synonyms
COL12A1; COL12A1LCollagen alpha-1(XII) chain
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