Recombinant Human Collectrin (TMEM27), Truncated

Uniprot Id

Q9HBJ8

Target Species

Human

Target Name

CLTRN

Target Full Name

Collectrin

Target Function

Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Protein Families

TMEM27 family

Target Tissue Specificity

Kidney; collecting ducts. Pancreas; beta cells of islets.

Target Synonyms

UNQ679; Collectrin; kidney-specific membrane protein; NX-17; NX17; PRO1312; Tmem27; TMM27_HUMAN; Transmembrane protein 27; UNQ679/PRO1312

Target Background

This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells.