Recombinant Human Complement component C7 (C7), Truncated

Uniprot Id

P10643

Target Species

Human

Target Name

C7

Target Full Name

Complement component C7

Target Function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.

Target Involvement

Complement component 7 deficiency (C7D)

Target Subcellular Location

Secreted.

Target Protein Families

Complement C6/C7/C8/C9 family

Target Synonyms

C7; CO7_HUMAN; complement component 7; Complement component C7

Target Background

This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency.