Recombinant Human Condensin-2 complex subunit H2 (NCAPH2)

Uniprot Id

Q6IBW4

Target Species

Human

Target Name

NCAPH2

Target Full Name

Condensin-2 complex subunit H2

Target Function

Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size. Seems to have lineage-specific role in T-cell development

Target Subcellular Location

Nucleus. Chromosome. Note=Distributed along the arms of chromosomes assembled in vivo and in vitro.

Target Protein Families

CND2 H2 (condensin-2 subunit 2) family

Target Synonyms

CAP H2; CAP H2 subunit of the condensin II complex; CAPH2; Chromosome associated protein H2; Chromosome-associated protein H2; CNDH2_HUMAN; Condensin-2 complex subunit H2; hCAP H2; hCAP-H2; Kleisin beta; Kleisin-beta; Ncaph2; Non SMC condensin II complex subunit H2; Non-SMC condensin II complex subunit H2