Recombinant Human Copine-6 (CPNE6)

Uniprot Id

O95741

Target Species

Human

Target Name

CPNE6

Target Full Name

Copine-6

Target Function

Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes.

Target Subcellular Location

Cytoplasm. Cell membrane. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Perikaryon. Cell projection, dendrite.

Target Protein Families

Copine family

Target Tissue Specificity

Widely expressed in the brain. Expressed weakly in the kidney, liver and fetal heart. Expressed in melanocytes.

Target Synonyms

Copine 6; Copine VI (neuronal); Copine VI; Copine-6; Copine6; CopineVI; CPNE 6; Cpne6; CPNE6_HUMAN; N copine; N-copine; Neuronal copine; Neuronal-copine

Target Background

This gene encodes a member of the copine family. Members of this family are calcium-dependent, phospholipid-binding proteins with C2 domains, two calcium- and phospholipid-binding domains. Through their domain structure and lipid binding capabilities, these proteins may play a role in membrane trafficking. This protein is thought to be brain-specific and has a domain structure of two N-terminal C2 domains and one von Willebrand factor A domain. It may have a role in synaptic plasticity.