Recombinant Human Cyclin-dependent kinase 14 (CDK14)

Uniprot Id

O94921

Target Species

Human

Target Name

CDK14

Target Full Name

Cyclin-dependent kinase 14

Target Function

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport

Target Subcellular Location

Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY.

Target Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily

Target Tissue Specificity

Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected.

Target Synonyms

cdk14; CDK14_HUMAN; Cell division protein kinase 14; Cyclin-dependent kinase 14; hPFTAIRE1; KIAA0834; mKIAA0834; PFTAIRE protein kinase 1; PFTAIRE1; PFTK1; Serine/threonine protein kinase PFTAIRE 1; Serine/threonine-protein kinase PFTAIRE-1