Recombinant Human Cyclin-dependent kinase 4 inhibitor D (CDKN2D)

Uniprot Id

P55273

Target Species

Human

Target Name

CDKN2D

Target Full Name

Cyclin-dependent kinase 4 inhibitor D

Target Function

Interacts strongly with CDK4 and CDK6 and inhibits them.

Target Subcellular Location

Nucleus. Cytoplasm.

Target Protein Families

CDKN2 cyclin-dependent kinase inhibitor family

Target Research Area

Cell Biology

Target Synonyms

CDKN2DCyclin-dependent kinase 4 inhibitor D; p19-INK4d

Target Background

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.