Recombinant Human Cysteine-rich protein 2-binding protein (KAT14)

Uniprot Id

Q9H8E8

Target Species

Human

Target Name

KAT14

Target Full Name

Cysteine-rich protein 2-binding protein

Target Function

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.

Target Subcellular Location

Nucleus. Cytoplasm. Note=Mainly nuclear.

Target Tissue Specificity

Expressed in skeletal muscle, heart, lung, placenta, brain, liver, pancreas and kidney. High expression in skeletal muscle and heart. Lower expression in lung.

Target Research Area

Cancer

Target Synonyms

ADA2A containing complex subunit 2; ADA2A-containing complex subunit 2; ATAC2; CRP2 binding partner; CRP2-binding partner; CRP2BP; CSR2B_HUMAN; CSRP2 binding protein; CSRP2-binding protein; Csrp2bp; Cysteine rich protein 2 binding protein; Cysteine-rich protein 2-binding protein

Target Background

CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described.