Recombinant Human Cytidine deaminase (CDA)

Uniprot Id

P32320

Target Species

Human

Target Name

CDA

Target Full Name

Cytidine deaminase

Target Function

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

Target Protein Families

Cytidine and deoxycytidylate deaminase family

Target Tissue Specificity

Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

CDA; CDDCytidine deaminase; EC 3.5.4.5; Cytidine aminohydrolase

Target Background

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.