Recombinant Human Cytochrome b (MT-CYB), Truncated

Uniprot Id

P00156

Target Species

Human

Target Name

MT-CYB

Target Full Name

Cytochrome b

Target Function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Target Involvement

Cardiomyopathy, infantile histiocytoid (CMIH); Leber hereditary optic neuropathy (LHON)

Target Subcellular Location

Mitochondrion inner membrane; Multi-pass membrane protein.

Target Protein Families

Cytochrome b family

Target Synonyms

COB; Complex III subunit 3; Complex III subunit III; CYB_HUMAN; CYTB; Cytochrome b; Cytochrome b c1 complex subunit 3; Cytochrome b-c1 complex subunit 3; Mitochondrially encoded cytochrome b; MT-CYB; MTCYB; Ubiquinol cytochrome c reductase complex cytochrome b subunit; Ubiquinol-cytochrome-c reductase complex cytochrome b subunit

Target Background

Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including electron transport coupled proton transport; response to cobalamin; and response to glucagon. Located in mitochondrion. Implicated in ovarian carcinoma and urinary bladder cancer.