Recombinant Human Cytochrome c oxidase subunit 8C, mitochondrial (COX8C), Truncated

Uniprot Id

Q7Z4L0

Target Species

Human

Target Name

COX8C

Target Full Name

Cytochrome c oxidase subunit 8C, mitochondrial

Target Function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix

Target Subcellular Location

Mitochondrion inner membrane; Single-pass membrane protein.

Target Protein Families

Cytochrome c oxidase VIII family

Target Tissue Specificity

It is not yet known where COX8C is expressed.

Target Synonyms

COX8CCytochrome c oxidase subunit 8C; mitochondrial; Cytochrome c oxidase polypeptide 8 isoform 3; Cytochrome c oxidase polypeptide VIII isoform 3; COX VIII-3; Cytochrome c oxidase subunit 8-3; COX8-3; Cytochrome c oxidase subunit VIIIC