Recombinant Human DDRGK domain-containing protein 1 (DDRGK1)

Cat.No	ACP12908	Target Name	DDRGK1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	29-314	Protein Length	Full Length of Mature Protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP12908

Target Name

DDRGK1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

29-314

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q96HY6

Background Information

Uniprot Id

Q96HY6
Target Species

Human
Target Name

DDRGK1
Target Full Name

DDRGK domain-containing protein 1
Target Function

Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy). In response to endoplasmic reticulum stress, promotes recruitment of the E3 UFM1-protein ligase UFL1 to the endoplasmic reticulum membrane: in turn, UFL1 mediates ufmylation of proteins such as RPN1 and RPL26/uL24, promoting reticulophagy of endoplasmic reticulum sheets. Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability. Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis or inflammatory response. Required for TRIP4 ufmylation, thereby regulating nuclear receptors-mediated. transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B. Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator
Target Subcellular Location

Endoplasmic reticulum. Endoplasmic reticulum membrane.
Target Protein Families

DDRGK1 family
Target Tissue Specificity

Widely expressed (at protein level). In the brain, highest levels in medulla oblongata, followed by cerebral cortex, cerebellum and frontal lobe.
Target Synonyms

1110001I20Rik; 2600009E05Rik; C20orf116; Chromosome 20 open reading frame 116; Dashurin; DDRGK domain containing 1; DDRGK domain containing protein 1; DDRGK domain-containing protein 1; DDRGK_HUMAN; Ddrgk1; dJ1187M17.3; MGC2592; OTTHUMP00000030088; RGD1309979; RP23-100C5.9; UFM1-binding and PCI domain-containing protein 1

Recombinant Human DDRGK domain-containing protein 1 (DDRGK1)

Specifications

Immunogen Information

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