Recombinant Human Decorin (DCN)

Uniprot Id

P07585

Target Species

Human

Target Name

DCN

Target Full Name

Decorin

Target Function

May affect the rate of fibrils formation.

Target Involvement

Corneal dystrophy, congenital stromal (CSCD)

Target Subcellular Location

Secreted, extracellular space, extracellular matrix.

Target Protein Families

Small leucine-rich proteoglycan (SLRP) family, SLRP class I subfamily

Target Research Area

Signal Transduction

Target Synonyms

Bone proteoglycan II; CSCD; DCN; DCN protein; Decorin; Decorin proteoglycan; Dermatan sulphate proteoglycans II ; DKFZp686J19238; DSPG 2; DSPG2; PG 40; PG II; PG S2; PG-S2; PG40; PGII ; PGS 2; PGS2; PGS2_HUMAN; Proteoglycan core protein ; SLRR1B; Small leucine rich protein 1B

Target Background

This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients.