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Recombinant Human Dedicator of cytokinesis protein 8 (DOCK8), Truncated

ACP02048

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Specifications

Cat.No	ACP02048	Target Name	DOCK8
Target Synonyms	DOCK8Dedicator of cytokinesis protein 8	Form	Liquid or Lyophilized powder
Expression System	Yeast	Expression Range	560-729aa
Mol Weight	21.8kDa	Protein Length	Partial
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q8NF50

Background Information

Uniprot Id

Q8NF50
Target Species

Human
Target Name

DOCK8
Target Full Name

Dedicator of cytokinesis protein 8
Target Function

Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing.
Target Involvement

Hyperimmunoglobulin E recurrent infection syndrome, autosomal recessive (AR-HIES); Mental retardation, autosomal dominant 2 (MRD2)
Target Subcellular Location

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families

DOCK family
Target Tissue Specificity

Expressed in peripheral blood mononuclear cells (PBMCs).
Target Research Area

others
Target Synonyms

DOCK8Dedicator of cytokinesis protein 8

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Recombinant Human Dedicator of cytokinesis protein 8 (DOCK8), Truncated

Specifications

Immunogen Information

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