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Advance your metabolism research with the Recombinant Human DLAT protein, a critical component of the pyruvate dehydrogenase complex. This mitochondrial enzyme plays a central role in the production of cellular energy, acting as the dihydrolipoyllysine-residue acetyltransferase, responsible for acetyl group transfer during the conversion of pyruvate to acetyl-CoA. Our Recombinant Human DLAT protein is derived from E.coli and comprises the 93-640aa expression region, corresponding to a partial segment of the native protein. Featuring an N-terminal 6xHis tag, this protein is easily purified and detected, ensuring optimal performance in your experiments. With a purity greater than 90% as determined by SDS-PAGE, this protein delivers consistent results in various applications. Choose between liquid and lyophilized powder forms to best suit your research needs and experimental design.
Advance your metabolism research with the Recombinant Human DLAT protein, a critical component of the pyruvate dehydrogenase complex. This mitochondrial enzyme plays a central role in the production of cellular energy, acting as the dihydrolipoyllysine-residue acetyltransferase, responsible for acetyl group transfer during the conversion of pyruvate to acetyl-CoA.
Our Recombinant Human DLAT protein is derived from E.coli and comprises the 93-640aa expression region, corresponding to a partial segment of the native protein. Featuring an N-terminal 6xHis tag, this protein is easily purified and detected, ensuring optimal performance in your experiments. With a purity greater than 90% as determined by SDS-PAGE, this protein delivers consistent results in various applications. Choose between liquid and lyophilized powder forms to best suit your research needs and experimental design.
| Cat.No | ACP02772 | Target Name | DLAT |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 93-640aa | Mol Weight | 62.2kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P10515 |
|---|
Uniprot Id
P10515
Target Species
Human
Target Name
DLAT
Target Full Name
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Target Function
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Target Involvement
Pyruvate dehydrogenase E2 deficiency (PDHE2 deficiency)
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
2-oxoacid dehydrogenase family
Target Research Area
Metabolism
Target Synonyms
70 kDa mitochondrial autoantigen of primary biliary cirrhosis; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide S Acetyltransferase; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial; DLAT; DLTA; E2; E2 component of pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit; mitochondrial; ODP2_HUMAN; PBC; PDC E2; PDC-E2; PDCE2; Pyruvate dehydrogenase complex component E2; Pyruvate dehydrogenase complex E2 subunit
Target Background
This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.
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