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An entire Dihydropyrimidinase-related protein 2 (DPYSL2)?ORF inserted a 6xHis-tag at the N-terminus was expressed in the yeast cells. The generated protein is the recombinant full-length fusion DPYSL2 containing 1-572aa of human DPYSL2. The SDS-PAGE analysis measured its purity up to 90%, and it has a calculated molecular mass of 64.3 kDa. It also underwent validation by the LC-MS/MS analysis. In-stock DPYSL2 proteins are offered now. This recombinant DPYSL2 protein may find uses in the production of anti-DPYSL2 antibodies or in the studies of developmental biology. DPYSL2, also called CRMP2, is a cytosolic protein belonging to the five-gene family known for its implication in axonal growth cone collapse. DPYSL2 mediates axonal outgrowth in the developing brain by enhancing microtubule assembly, vesicle trafficking, and synaptic physiology. DPYSL2 interacting with other proteins stabilizes microtubules, facilitates neurite outgrowth, and regulates signaling processes in the central nervous system (CNS). The ablation of DPYSL2 may lead to neurodevelopmental disorders including unregulated axon growth and branching, which suggests that DPYSL2 plays a crucial role in the pathogenesis of schizophrenia. Liu-Lin Xiong etc. demonstrated that an increase of DPYSL2 expression promotes neural stem cells (NSCs) differentiates into neurons.
An entire Dihydropyrimidinase-related protein 2 (DPYSL2)?ORF inserted a 6xHis-tag at the N-terminus was expressed in the yeast cells. The generated protein is the recombinant full-length fusion DPYSL2 containing 1-572aa of human DPYSL2. The SDS-PAGE analysis measured its purity up to 90%, and it has a calculated molecular mass of 64.3 kDa. It also underwent validation by the LC-MS/MS analysis. In-stock DPYSL2 proteins are offered now. This recombinant DPYSL2 protein may find uses in the production of anti-DPYSL2 antibodies or in the studies of developmental biology.
DPYSL2, also called CRMP2, is a cytosolic protein belonging to the five-gene family known for its implication in axonal growth cone collapse. DPYSL2 mediates axonal outgrowth in the developing brain by enhancing microtubule assembly, vesicle trafficking, and synaptic physiology. DPYSL2 interacting with other proteins stabilizes microtubules, facilitates neurite outgrowth, and regulates signaling processes in the central nervous system (CNS). The ablation of DPYSL2 may lead to neurodevelopmental disorders including unregulated axon growth and branching, which suggests that DPYSL2 plays a crucial role in the pathogenesis of schizophrenia. Liu-Lin Xiong etc. demonstrated that an increase of DPYSL2 expression promotes neural stem cells (NSCs) differentiates into neurons.
| Cat.No | ACP02543 | Target Name | DPYSL2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Yeast |
| Expression Range | 1-572aa | Mol Weight | 64.3kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q16555 |
|---|
Uniprot Id
Q16555
Target Species
Human
Target Name
DPYSL2
Target Full Name
Dihydropyrimidinase-related protein 2
Target Function
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Target Subcellular Location
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane. Note=Tightly but non-covalently associated with membranes.
Target Protein Families
Metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family
Target Tissue Specificity
Ubiquitous.
Target Research Area
Developmental Biology
Target Synonyms
Collapsin response mediator protein 2; Collapsin response mediator protein; Collapsin response mediator protein hCRMP 2; CRAM; CRMP 2; CRMP-2; CRMP2; DHPRP 2; DHPRP2; Dihydropyrimidinase 2; Dihydropyrimidinase like 2; Dihydropyrimidinase like 2 long form; Dihydropyrimidinase related protein 2; Dihydropyrimidinase-related protein 2; DPYL 2; DPYL2; DPYL2_HUMAN; DPYSL 2; Dpysl2; DRP-2; DRP2; Musunc 33; Musunc33; N2A3; TOAD 64; TOAD64; ULIP 2 protein; ULIP-2; Ulip2; Unc-33-like phosphoprotein 2
Target Background
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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