Home Products Recombinant Human DIS3-like exonuclease 2 (DIS3L2), Truncated

Recombinant Human DIS3-like exonuclease 2 (DIS3L2), Truncated

ACP14936

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Specifications

Cat.No	ACP14936	Target Name	DIS3L2
Target Synonyms	DI3L2_HUMAN; DIS3 L2; DIS3 mitotic control homolog (S. cerevisiae) like 2; DIS3 mitotic control homolog like 2; DIS3-like exonuclease 2; Dis3l2; FLJ36974; MGC42174	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q8IYB7

Background Information

Uniprot Id

Q8IYB7
Target Species

Human
Target Name

DIS3L2
Target Full Name

DIS3-like exonuclease 2
Target Function

3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
Target Involvement

Perlman syndrome (PRLMNS)
Target Subcellular Location

Cytoplasm. Cytoplasm, P-body.
Target Protein Families

RNR ribonuclease family, DIS3L2 subfamily
Target Synonyms

DI3L2_HUMAN; DIS3 L2; DIS3 mitotic control homolog (S. cerevisiae) like 2; DIS3 mitotic control homolog like 2; DIS3-like exonuclease 2; Dis3l2; FLJ36974; MGC42174

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Recombinant Human DIS3-like exonuclease 2 (DIS3L2), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human DIS3-like exonuclease 2 (DIS3L2), Truncated Now

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