Recombinant Human Disheveled-associated activator of morphogenesis 1 (DAAM1), Truncated

Uniprot Id

Q9Y4D1

Target Species

Human

Target Name

DAAM1

Target Full Name

Disheveled-associated activator of morphogenesis 1

Target Function

Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Together with DAAM2, required for myocardial maturation and sarcomere assembly.

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Note=Perinuclear.

Target Protein Families

Formin homology family

Target Tissue Specificity

Expressed in all tissues examined.

Target Synonyms

DAAM1; KIAA0666; Disheveled-associated activator of morphogenesis 1

Target Background

Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins.