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| Cat.No | ACP01401 | Target Name | DCLRE1A |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 690-1040aa | Mol Weight | 4.1 kDa |
| Protein Length | Partial | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6PJP8 |
|---|
Uniprot Id
Q6PJP8
Target Species
Human
Target Name
DCLRE1A
Target Full Name
DNA cross-link repair 1A protein
Target Function
May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin. Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem).
Target Subcellular Location
Nucleus. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11, RAD50 and NBN) and BRCA1.
Target Protein Families
DNA repair metallo-beta-lactamase (DRMBL) family
Target Tissue Specificity
Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
Dclre1a; DCR1A_HUMAN; DNA cross link repair 1A; DNA cross link repair gene SNM1; DNA cross-link repair 1A protein; hSNM1; hSNM1A; PSO2; SNM1 homolog A
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