Recombinant Human DNA-directed RNA polymerase I subunit RPA2 (POLR1B), Truncated

Uniprot Id

Q9H9Y6

Target Species

Human

Target Name

POLR1B

Target Full Name

DNA-directed RNA polymerase I subunit RPA2

Target Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

Target Subcellular Location

Nucleus, nucleolus. Chromosome.

Target Protein Families

RNA polymerase beta chain family

Target Synonyms

A127; DNA directed RNA polymerase I 135kDa polypeptide; DNA directed RNA polymerase I; DNA directed RNA polymerase I subunit RPA2; DNA-directed RNA polymerase I 135 kDa polypeptide; DNA-directed RNA polymerase I subunit rpa2; FLJ10816; FLJ21921; MGC131780; OTTHUMP00000161989; OTTHUMP00000203643; OTTHUMP00000203645; POLR 1B; polr1b; Polymerase (RNA) I polypeptide B 128kDa; Polymerase (RNA) I polypeptide B; RNA polymerase I polypeptide B; RNA polymerase I subunit 2; RPA 135; RPA116; RPA135; RPA2; RPA2_HUMAN; Rpo1 2

Target Background

Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).