Recombinant Human DNA-directed RNA polymerase I subunit RPA49 (POLR1E)

Uniprot Id

Q9GZS1

Target Species

Human

Target Name

POLR1E

Target Full Name

DNA-directed RNA polymerase I subunit RPA49

Target Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF.

Target Subcellular Location

Nucleus, nucleolus.

Target Protein Families

Eukaryotic RPA49/POLR1E RNA polymerase subunit family

Target Synonyms

A49; DNA directed RNA polymerase I subunit RPA49; DNA-directed RNA polymerase I subunit E; DNA-directed RNA polymerase I subunit RPA49; FLJ 13390; FLJ13970; PAF53; POLR 1 E; POLR1E; Polymerase (RNA) I associated factor 1; Polymerase (RNA) I polypeptide E; Polymerase (RNA) I polypeptide E, 53kDa; PRAF1; RNA polymerase I associated factor 1; RNA polymerase I associated factor 53; RNA polymerase I polypeptide E; RNA polymerase I subunit A49; RNA polymerase I-associated factor 1; RNA polymerase I-associated factor 53; RP11405L18.3; RPA49_HUMAN

Target Background

Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and RNA polymerase I general transcription initiation factor binding activity. Involved in nucleolar large rRNA transcription by RNA polymerase I. Located in fibrillar center and nucleoplasm.