Recombinant Human DNA oxidative demethylase ALKBH2 (ALKBH2)

Uniprot Id

Q6NS38

Target Species

Human

Target Name

ALKBH2

Target Full Name

DNA oxidative demethylase ALKBH2

Target Function

Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.

Target Subcellular Location

Nucleus. Note=Detected in replication foci during S-phase.

Target Protein Families

AlkB family

Target Tissue Specificity

Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

2OG Fe(II) oxy DC1; 9530023G02 ; ABH 2; ABH2; alkB alkylation repair homolog 2; ALKB2_HUMAN; ALKBH2 alkB; ALKBH2; Alkylated DNA repair protein alkB homolog ; Alkylated DNA repair protein alkB homolog 2; Alkylation repair homolog 2; Alpha ketoglutarate dependent dioxygenase alkB homolog 2; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; AU016977; DNA oxidative demethylase ALKBH2; EC 1.14.11.; FLJ99103; hABH2; mABH2; MGC90512 ; Oxy DC1

Target Background

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).