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Recombinant Human DnaJ homolog subfamily C member 3 (DNAJC3)

ACP18292

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Specifications

Cat.No	ACP18292	Target Name	DNAJC3
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	32-504	Protein Length	Full Length of Mature Protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q13217

Background Information

Uniprot Id

Q13217
Target Species

Human
Target Name

DNAJC3
Target Full Name

DnaJ homolog subfamily C member 3
Target Function

Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
Target Involvement

Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus (ACPHD)
Target Subcellular Location

Endoplasmic reticulum.
Target Tissue Specificity

Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.
Target Synonyms

DnaJ (Hsp40) homolog subfamily C member 3; DnaJ homolog subfamily C member 3; DNAJC3; DNJC3_HUMAN; double-stranded RNA-activated protein kinase inhibitor; Endoplasmic reticulum DnaJ protein 6; ERdj6; HP58; Interferon induced; double stranded RNA activated protein kinase inhibitor; Interferon-induced; P58; p58 ipk; P58IPK; PRKRI; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58; Protein kinase interferon inducible double stranded RNA dependent inhibitor

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Recombinant Human DnaJ homolog subfamily C member 3 (DNAJC3)

Specifications

Immunogen Information

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