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Recombinant Human Down syndrome critical region protein 3 (DSCR3)

ACP21398

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Specifications

Cat.No	ACP21398	Target Name	DSCR3
Target Synonyms	VPS26C; DCRA; DSCR3; DSCRA; Vacuolar protein sorting-associated protein 26C; Down syndrome critical region protein 3; Down syndrome critical region protein A	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-297
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	O14972

Background Information

Uniprot Id

O14972
Target Species

Human
Target Name

VPS26C
Target Full Name

Vacuolar protein sorting-associated protein 26C
Target Function

Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.; (Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface
Target Subcellular Location

Endosome.
Target Protein Families

VPS26 family
Target Tissue Specificity

Ubiquitously expressed.
Target Synonyms

VPS26C; DCRA; DSCR3; DSCRA; Vacuolar protein sorting-associated protein 26C; Down syndrome critical region protein 3; Down syndrome critical region protein A

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Recombinant Human Down syndrome critical region protein 3 (DSCR3)

Specifications

Immunogen Information

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