Recombinant Human E3 ubiquitin-protein ligase MARCH8 (41341), Truncated

Uniprot Id

Q5T0T0

Target Species

Human

Target Name

MARCHF8

Target Full Name

E3 ubiquitin-protein ligase MARCHF8

Target Function

E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.

Target Subcellular Location

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.

Target Tissue Specificity

Broadly expressed. Present in immature dendritic cells (at protein level).

Target Synonyms

MARCHF8; MARCH8; MIR; RNF178; E3 ubiquitin-protein ligase MARCHF8; Cellular modulator of immune recognition; c-MIR; Membrane-associated RING finger protein 8; Membrane-associated RING-CH protein VIII; MARCH-VIII; RING finger protein 178; RING-type E3 ubiquitin transferase MARCHF8

Target Background

MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).