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| Cat.No | ACP10859 | Target Name | RNF181 |
|---|---|---|---|
| Target Synonyms | RNF181; HSPC238; E3 ubiquitin-protein ligase RNF181; EC 2.3.2.27; RING finger protein 181; RING-type E3 ubiquitin transferase RNF181 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-153 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9P0P0 |
|---|
Uniprot Id
Q9P0P0
Target Species
Human
Target Name
RNF181
Target Full Name
E3 ubiquitin-protein ligase RNF181
Target Function
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Target Protein Families
RNF181 family
Target Tissue Specificity
Widely expressed, with highest levels in liver and heart and lowest levels in brain and skeletal muscle. Expressed in platelets (at protein level).
Target Synonyms
RNF181; HSPC238; E3 ubiquitin-protein ligase RNF181; EC 2.3.2.27; RING finger protein 181; RING-type E3 ubiquitin transferase RNF181
Target Background
RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).
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