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| Cat.No | ACP15675 | Target Name | TRIM50 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-487 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q86XT4 |
|---|
Uniprot Id
Q86XT4
Target Species
Human
Target Name
TRIM50
Target Full Name
E3 ubiquitin-protein ligase TRIM50
Target Function
E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction.
Target Subcellular Location
Cytoplasm.
Target Protein Families
TRIM/RBCC family
Target Synonyms
E3 ubiquitin ligase ; E3 ubiquitin protein ligase TRIM50; E3 ubiquitin-protein ligase TRIM50; TRI50_HUMAN; TRIM50; TRIM50A ; Tripartite motif containing 50; Tripartite motif containing protein 50; Tripartite motif protein 50; tripartite motif protein 50A ; tripartite motif-containing 50A ; Tripartite motif-containing protein 50
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