Home Products Recombinant Human EF-hand domain-containing family member A1 (EFHA1)

Recombinant Human EF-hand domain-containing family member A1 (EFHA1)

ACP14930

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Specifications

Cat.No	ACP14930	Target Name	MICU2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-434	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q8IYU8

Background Information

Uniprot Id

Q8IYU8
Target Species

Human
Target Name

MICU2
Target Full Name

Calcium uptake protein 2, mitochondrial
Target Function

Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering.
Target Subcellular Location

Mitochondrion intermembrane space.
Target Protein Families

MICU1 family, MICU2 subfamily
Target Synonyms

1110008L20Rik; EF hand domain containing family member A1; EF hand domain family A1; EF hand domain family member A1; EF-hand domain-containing family member A1; EFHA1; EFHA1 EF hand domain family member A1; EFHA1_HUMAN; FLJ25016; FLJ34588; Smhs2 homolog
Target Background

Enables protein heterodimerization activity. Involved in calcium import into the mitochondrion and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of uniplex complex.

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Recombinant Human EF-hand domain-containing family member A1 (EFHA1)

Specifications

Immunogen Information

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