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| Cat.No | ACP20086 | Target Name | ERVK-8 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P63133 |
|---|
Uniprot Id
P63133
Target Species
Human
Target Name
ERVK-8
Target Full Name
Endogenous retrovirus group K member 8 Pol protein
Target Function
Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.
Target Protein Families
Beta type-B retroviral polymerase family, HERV class-II K(HML-2) pol subfamily
Target Synonyms
ERVK-8; Endogenous retrovirus group K member 8 Pol protein; HERV-K115 Pol protein; HERV-K_8p23.1 provirus ancestral Pol protein) [Includes: Reverse transcriptase; RT; EC 2.7.7.49); Ribonuclease H; RNase H; EC 3.1.26.4); Integrase; IN)]
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