Recombinant Human Endoplasmic reticulum aminopeptidase 2 (ERAP2), Truncated

Uniprot Id

Q6P179

Target Species

Human

Target Name

ERAP2

Target Full Name

Endoplasmic reticulum aminopeptidase 2

Target Function

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.

Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Target Protein Families

Peptidase M1 family

Target Tissue Specificity

Ubiquitously expressed. Highly expressed in spleen and leukocytes.

Target Synonyms

ERAP2; LRAPEndoplasmic reticulum aminopeptidase 2; EC 3.4.11.-; Leukocyte-derived arginine aminopeptidase; L-RAP

Target Background

This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5.