Recombinant Human Engulfment and cell motility protein 1 (ELMO1)

Uniprot Id

Q92556

Target Species

Human

Target Name

ELMO1

Target Full Name

Engulfment and cell motility protein 1

Target Function

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

Target Subcellular Location

Cytoplasm. Cell membrane. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.

Target Tissue Specificity

Widely expressed, with a higher expression in the spleen and placenta.

Target Synonyms

CED 12; Ced 12 homolog 1; Ced 12 homolog; CED-12; CED12; Ced12 homolog 1; Ced12 homolog; ELMO 1; ELMO-1; Elmo1; ELMO1_HUMAN; Engulfment and cell motility 1; Engulfment and cell motility protein 1; KIAA0281; MGC126406; Protein ced-12 homolog

Target Background

This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants.