Recombinant Human Enhancer of polycomb homolog 1 (EPC1), Truncated

Uniprot Id

Q9H2F5

Target Species

Human

Target Name

EPC1

Target Full Name

Enhancer of polycomb homolog 1

Target Function

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage

Target Subcellular Location

Nucleus.

Target Protein Families

Enhancer of polycomb family

Target Synonyms

DKFZp781P2312; Enhancer of polycomb 1; Enhancer of polycomb homolog 1 (Drosophila); Enhancer of polycomb homolog 1; EPC1; EPC1_HUMAN; Epl 1; Epl1; OTTHUMP00000046260

Target Background

This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants.