Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The expression region of this recombinant Human ESR2 covers amino acids 2-323. This ESR2 protein is expected to have a theoretical molecular weight of 39.8 kDa. This protein is generated in a e.coli-based system. The ESR2 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant ESR2 protein during the following stages.Human estrogen receptor beta (ESR2) is a nuclear hormone receptor that plays a crucial role in mediating the physiological effects of estrogen. It is a member of the steroid hormone receptor superfamily and is expressed in various tissues, including the reproductive, cardiovascular, and central nervous systems. ESR2 functions as a transcription factor, regulating gene expression in response to estrogen binding. Its activation influences diverse processes such as cell proliferation, differentiation, and apoptosis. ESR2 is particularly involved in modulating the effects of estrogen in non-reproductive tissues. Research on ESR2 has implications for understanding hormone-dependent diseases, including certain cancers and exploring therapeutic interventions related to hormonal regulation.
The expression region of this recombinant Human ESR2 covers amino acids 2-323. This ESR2 protein is expected to have a theoretical molecular weight of 39.8 kDa. This protein is generated in a e.coli-based system. The ESR2 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant ESR2 protein during the following stages.Human estrogen receptor beta (ESR2) is a nuclear hormone receptor that plays a crucial role in mediating the physiological effects of estrogen. It is a member of the steroid hormone receptor superfamily and is expressed in various tissues, including the reproductive, cardiovascular, and central nervous systems. ESR2 functions as a transcription factor, regulating gene expression in response to estrogen binding. Its activation influences diverse processes such as cell proliferation, differentiation, and apoptosis. ESR2 is particularly involved in modulating the effects of estrogen in non-reproductive tissues. Research on ESR2 has implications for understanding hormone-dependent diseases, including certain cancers and exploring therapeutic interventions related to hormonal regulation.
| Cat.No | ACP02474 | Target Name | ESR2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-323AA of Isoform 3 | Mol Weight | 39.8kDa |
| Protein Length | Partial of Isoform 3 | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q92731 |
|---|
Uniprot Id
Q92731
Target Species
Human
Target Name
ESR2
Target Full Name
Estrogen receptor beta
Target Function
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
Target Subcellular Location
Nucleus.
Target Protein Families
Nuclear hormone receptor family, NR3 subfamily
Target Tissue Specificity
[Isoform 1]: Expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, b
Target Research Area
Transcription
Target Synonyms
ER BETA; ER-beta; Erb; ESR B; ESR BETA; ESR2; ESR2_HUMAN; ESRB; ESTRB; estrogen nuclear receptor beta variant a; estrogen nuclear receptor beta variant b; estrogen receptor 2 (ER beta); Estrogen receptor 2; estrogen receptor beta 4; Estrogen receptor beta; NR3A2; Nuclear receptor subfamily 3 group A member 2
Target Background
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
