Recombinant Human Excitatory amino acid transporter 1 (SLC1A3), Truncated

Cat.No	ACP01907	Target Name	SLC1A3
Target Synonyms	Sodium-dependent glutamate/aspartate transporter 1;GLAST-1;Solute carrier family 1 member 3	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	146-236aa
Mol Weight	25.5 kDa	Protein Length	Partial
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP01907

Target Name

SLC1A3

Target Synonyms

Sodium-dependent glutamate/aspartate transporter 1;GLAST-1;Solute carrier family 1 member 3

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

146-236aa

Mol Weight

25.5 kDa

Protein Length

Partial

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P43003

Background Information

Uniprot Id

P43003
Target Species

Human
Target Name

SLC1A3
Target Full Name

Excitatory amino acid transporter 1
Target Function

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate.
Target Involvement

Episodic ataxia 6 (EA6)
Target Subcellular Location

Cell membrane; Multi-pass membrane protein.
Target Protein Families

Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family, SLC1A3 subfamily
Target Tissue Specificity

Detected in brain. Detected at very much lower levels in heart, lung, placenta and skeletal muscle. Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia.
Target Research Area

Neuroscience
Target Synonyms

EA6; EAA1_HUMAN; EAAT1; Excitatory amino acid transporter 1; FLJ25094 ; GLAST; GLAST-1; GLAST1; Glial high affinity glutamate transporter; glutamate/aspartate transporter; high affinity; sodium-dependent; High affinity neuronal glutamate transporter; Slc1a3; Sodium dependent glutamate/aspartate transporter; Sodium-dependent glutamate/aspartate transporter 1; Solute carrier family 1 (glial high affinity glutamate transporter) member 3; Solute carrier family 1 member 3
Target Background

This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.

Recombinant Human Excitatory amino acid transporter 1 (SLC1A3), Truncated

Specifications

Immunogen Information

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