Recombinant Human Extracellular sulfatase Sulf-1 (SULF1), Truncated

Uniprot Id

Q8IWU6

Target Species

Human

Target Name

SULF1

Target Full Name

Extracellular sulfatase Sulf-1

Target Function

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.

Target Subcellular Location

Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface.

Target Protein Families

Sulfatase family

Target Tissue Specificity

Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, brea

Target Synonyms

DSulf; Extracellular sulfatase Sulf 1; Extracellular sulfatase Sulf-1; Extracellular sulfatase Sulf1 ; HSULF 1; HSulf-1; Neu5; Sulf1; SULF1_HUMAN; Sulfatase FP; Sulfated

Target Background

This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants.